Scott Harrison - The golden apples
Henry Parker's Robot Wars





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Info:  forefront of a revolution in drug discovery and development by combining advanced AI and ML with cutting-edge science to decipher complex disease biology and discover optimum therapeutic interventions.

1. bring effective drugs to patients 2. molecular design for the right patient 3. billion relationships between genes and targets and diseases and proteins.
Posted:10/10/2022


Recursion Pharmaceuticals

Info:  Recursion Pharmaceuticals’ integrated Recursion Operating System, a closed-loop system combining proprietary in-house data generation and advanced computational tools to generate novel insights to initiate or accelerate therapeutic programs, is building innovations across biology, chemistry, automation, data science, and engineering to industrialize drug discovery to target such diseases as cancer.

1. industrializes the discovery of medicine 2. 90 percent of drugs that go into clinical trials fail 3. use of robotics to find medicines that work for a patient through trial and error 4. they believe in lowering the cost of medicines 5. four medicines that entering into phase two trials 6. 19 billion dollar partnership with roche to create medicines for neuroscience diseases
Posted:10/10/2022


Ginkgo

Info: Ginkgo Bioworks is a biotech company from the United States that specializes in using genetic engineering to produce bacteria with industrial applications for its clients.

1. programming the dna of cells allowing the programming of cells.

2. biological apps that run the ginkgo platform

3. 4 billion dollars in contracts

4. for example, increasing the vaccine production in cells, food production, antibotics

5. Ginkgo is a 15 billion dollar enterprise

6. introducing gene therapy technology using their programmable cell

7. stardust: launch a startup company using ginkgo platform. outsource the biotech to ginkgo

8. ginkgo has 50 cell programs for customers
Posted:10/10/2022


The rise of social networks and their usefulness

Info: HOW DOES INFORMATION TRAVEL THROUGH A POPULATION

1. The worlds data storage is 295 exabytes of information.

2. Information increases by a factor of five every five years.

3. Peter Pirolli, cognitive psychologist has studied how people navigate and use information online. People search for information like animals search for food and have predictable patterns. People find, share and synthesize knowledge they have found. People are using the internet information to share health-care information, manage work system, and complete complex tasks. (Reference Link)

4. Foraging theory says animals try to maximize the amount of food that take in during a given amount of time. Birds search through scarce patches to find rich patches of food. Internet sites rich with information are strong forging areas for people. People follow a scent of key words, pictures, and clues to find the information.

5. People synthesize information efficiently in a group.

6. People are more likely to befriend genetically similar people when their environment is stratified. Two factors are critical: nature and nurture and nurture is more prevalent. (Reference Link)
Posted:12/25/2012


Strategy by Michael porter

Info: The basics of strategic competition

1. Understand competitive behavior 2. Understand how a strategy will rebalance competitive equilibrium 3. Understand commitment of resources even if deferred benefits 4. The ability to predict risk and return enough to make a commitment 5. The willingness to act

Barriers to entry 1. Scales to production, research, and marketing are barriers 2. To create barriers companies combine economies of scale with brand 3. Capital requirements limit entry into many markets 4. Entrenched companies may have cost advantage not available to potential reviles 5. A new product must displace existing product by cost reduction, promotions, intense selling efforts, or new distribution channels 6. Regulation can limit entry into a business

Suppliers can exert bargaining power by reducing profitability by raising prices or reducing the quality of their products

A supplier is strong if it does not have to contend with other products in the industry

Buyers find alternate suppliers and play one against another to reduce price or improve quality

Highly profitable buyers are less price sensitive . The buyer is interested in quality

Consumers are more sensitive to price purchasing an undifferentiated product where quality is not an issue

A company improves its strategic position by finding buyers and suppliers that can not a adversely affect it.

Strategy can be thought of as a defense against competition

Know how must be kept a secret to yield an advantage

Access advantages are vulnerable to shifts in availability or prices and sensitive to consumer preferences

Sustainable advantage is greatest when based on several kinds of advantages.

Industries that grow slowly offer more room to sustain advantages

Manufacturers are rebuilding their excellence in production

Stages of manufacturing effectiveness

Stage 1 Detailed management control systems are means to monitor performance Stage 1 struggles to provide adequate production, help suppliers with problems, and keep equipment up to date. Stage 1 relies on consultants for advice and knowledge. Stage 1 represents a build and assemble mentality.

Stage 2 Capital investment is the means to catch up with competition. Stage 2 avoids introduction of major discontinuous changes in product or process. Stage 2 follows industry practices. Stage 2 believes production rates due to new equipment as the measure of efficiency. Stage 2 have research and development labs they turn to in addition to consultants and suppliers. Stage 2 is increased in capacity gains.

Stage 3 Long term developments trends are developed systematically . Stage 2 is looking out for long term developments and trends that may affect the companies ability to meet needs. Companies arrive at stage 3 through the natural consequences of success in developing business strategy based on formal planning. Stage 3 view technology enhancement as the consequence of changes in business strategy

Stage 4 Long term programs are put into place to acquire capabilities in advance of needs Stage 4 anticipates new manufacturing practices and technologies. Stage 4 develop long term business plans where manufacturing capabilities play an important role. Manufacturing is a strategic resource.

The inertia of most large companies favors, a gradual, systematic, and cumulative movement through stages

Teamwork and problem solving is better than command and control

Moving to stage 4 involves changing how the organization thinks about manufacturing

Tighter intergration of product design and capabilities leads to flexibility

Mastery of activities at one stage provide the underpinnings for a successful transition to the next stage


Posted:11/10/2012


Why innovation could destroy a company in one year and how to manage innovation

Info: 1. ERP systems can not deliver all that is promised

2. Consulting is a dangerous game

3. Business Intelligence system are very complex and often do not deliver need functionality

4. Innovation needs to be managed by employees

5. Work experience improves production. Invest in talent and increased work knowledge.

6. Technology expansion should increase work value

7. There are Security risks associate with distributed information system. Why should companies be implementing tactics for controlling their security.
Posted:11/1/2012


Turnaround - Nissan - Ghosn

Info: The Ghosn thesis is "shed bad investment and build "growth long term by expanding product line". Growth and expansion is the America way. The America way is very different from other cultures in the world. Most business like slow and gradual change, but in high debt situations this is not possible. Companies expansion rapidly and increase profits.

Sears had 40 million shoppers and 20 million insurance policy holders. Sears decided not to expand but diversity. Sears diversification strategy was a mistake. Sears diversified into real estate, insurance, and financial investment services. Sears capital drains caused them to break the company up into a hold company with three parts.

Sears could have used their capital and expanded their stores. Sears could have been the Walgreens offering pharmacy and convenience. What went wrong?

Ghosn did focused on increasing product line introducing the 350Z and the Q35 luxury vehicle. Will Ghosn increase the number of hybrid electric vehicles on the product line reducing c02 emission and meeting new government regulation?

How did Ghosn shed bad debt. Ghosn received $5.4 billion from Renault as working capital. Ghosn began selling Nissan investments, stocks, and real estate in 1300 companies which not part of the core business. Ghosn used benchmarks to discover that part suppliers partners were earning 20-30 percent profit margins on all parts. A message was sent to the suppliers to cut prices by 20 percent in three years, 3-3-3 (suppliers, engineers, and purchasing), 3 years (US/Asia/Europe, Middle East, and Africa) and in return Nissan would increase volume purchases. Volume purchases increased a Nissan centralized purchasing and created a global network of purchasing. Vendors that agreed to Nissan pricing terms received contracts.

Ghosn used benchmarking comparison of Renault part price verses Nissan part price to determine price difference. The part network had created a close system with monopoly pricing. Ghosn decided to break up the network from Nissan perspective and return to free market principles. Ghosn realized that Nissan plants output was 50 percent of capacity. He reduced the plants by fifty percent increasing output capacity to 85% and earned the highest profits in Nissan history. Ghosn shed a significant amount of the $22 billion in debt within 3 years.

Ghosn knew that survival in business mean getting support from the business community and growing the product line. Ghosn returned the Z model cars and expanded the infinity model vehicle with Q45 being a very popular brand for infinity and 350Z being a great model for Nissan. Nissan GTR is the best super car on the market today.

Achieve 4.5 percent profit by 2002

By the end of 2001 Nissan reported a margin of 7.9 percent

Reduce net automotive debt by 50 percent

By 2001 net automotive debt was 435 billion yen

Reduce automotive supplier base by 40 percent

Reduce service suppliers by 60 percent

Close five plants and increase utilization rates to 75 percent

Reduce manufacturing platforms from 24 to 15

1 million unit sales by 2004, 8 percent profit margin, and zero debt

Reduce transaction price and resale gap with Toyota by 50 percent
Posted:10/27/2012


Toyota Talent: Developing Your People the Toyota Way

Info: Training in the work place is the empowerment that leads to job satisification. How do we develop talent? Learn by doing; focus on core tasks and then ancillary tasks; differiante talent into different type levels with different levels of autonomy and creativity; and help promote employee critical evaluation of tasks and assignments.

Developing talent results in critical evaluation of processes meaning the employee is free too think about problems and solutions or look for, inefficiencies and waste to eliminate. If one stopped, at critical evaluation, it would be enough; however, most people required structure to learn and change. Training is the beginning of the journey towards autonomy and self actualization.

The structure and design of Master trainer and group trainers is to provide insight into processes and learning. The Master trainer is a founder of thought and philosophy and establishes the culture of learning and vision of capability. The master trainer presides over the organization learning culture.

Job tasks can be broken down into definable segments. The more abstract the job the more generalized the principles of instruction. For example, a managers job tasks may differ in tasks from an engineer. However, the tasks should be describable and the goals and objectives measurable and capable of being written down. The Master training adheres to proven and long standing practices that ensure tasks can be learned. The employee should be capable of doing the task without thinking too much in a day dream state allowing him to critically think about what is happening.

Even in repetitious jobs critical evaluation is desired. Task breakdown allow the worker to be interchangeable with other workers. Temporary work can fit into the process without disruption. Temporary work will be able to learn the task processes and develop knowledge and empowerment, quickly.

The established order of work can proceed without interruption as new employees learn by doing. Employees in training should be able to evaluate and learn from real data gathered from the work place. The ability to perform a task should be more than a check list. Performing a task should include contineous improvement focused on three domains: manpower, machines, and material.

The objective of company management involves integration of the community with three areas of emphasis: manpower, machines, and material. The balance between manpower, machine, and material helps optimize a the system.

As robots become more capable and flexible and smart enough to work with human beings than machines will be used to assist the worker. The integration of machine into the work place expands as capability is demonstrated. Migration to machine aids production by combining manpower with machine and expanding his training.

As fabrication machines become more power than digital design will be more closely integrated with interchangeable machine parts. The flexible design will allow computer aided design to become more integrated into manufacturing. The third emphasis is materials. Material management and training will help reduce problems with scheduling, distribution, and payment of the materials.

Management of material will be assisted by advancing software. Training in the usage of the software will provided information about the life cycle of material and parts.

Just in Time software helped reduce waste in material management and lack of value added by manpower. In the future, Just in Time will integrate more closely with suppliers of materials too better match designs with company product specification. The idea of platform will become more powerful. Partners and vendors will perform to the platform objectives, attributes, and standards. The platform will expose the specifications and requirements to work with the platform. Acceptance will be determined by platform standards and qualification procedures. Platforms will provide scaleability. Knowledge workers will push for more flexible design and smarter integration of parts into the production process.

The shortage in any company is talent. A company is a community of people with various talent. The wisest investment for a company is to provide resources for community to get their job done and respect the knowledge at the place of action. Training migrates the employee through the job matrix and place him in the right role and job. Training helps the manager see where talent should migrate. A genius should not be assembling 400 parts a day. He should be thinking about creating 40,000 parts a day.
Posted:10/24/2012


The Ultimate Creation - Social Innovation

Info: 1. Great organizations do not necessarily make innovation a central part of their vision or strategy. For example, IBM was the not the technology leader but grew because of its sales force. Boeing did not invent the commercial jet but became the leader in commercial jet production. American Express was not the first to offer a consumer credit card and made its first offering 8 years after Diners club. Starbucks did not invent the high end coffee chain, Peets did. General Electric did not invent the AC electrical current, Westinghouse did. History is full of disfunct innovation leaders.

2. Being an innovative leader rarely proves to be a sustainable advantage.

3. The companies that survive are those that pursuit social innovation. Social innovation includes money, stock, corporations, free market economies, and public education. Culture and organization is what matters.

4. The greatest invention is human organization and the practice of management

5. People push standards and competition creates opportunities. Henry Ford’s innovation was the assembly line. Thomas Edison’s innovation was the modern research and development lab.

6. Creating a culture where people aspire to achieve the greatest that others have achieved is what makes the company great.


Posted:10/15/2012


Leading for Innovation

Info: 1. Arie De Geus says that innovation is one of the cause of short corporate life.

2. The optimization of people is a better way to ensure long term survival of a company

3. Innovation is a specific instrument of entrepreneurship. The entrepreneur brings in a certain degree of disequilibrium create opportunity to innovate. The casualty rate is high and the chance of survival and success low especially in areas of high visiblity.

4. "The Innovator Dilemma" states the average survival of a new commercial business is 12.5 years.

5. At least 45 of the largest corporations have survive the latest innovation destructive storm and survived successive technology waves.

6. Innovation needs to be managed. Innovation is capable of being learned and practiced. Why are some companies better a adapting and thriving in the technology storm?

7. Surviving companies are those who "see themselves as communities with a characteristic culture or ideology, which they combine with a pragmatic pursuit of profits."

8. A consensus exist that business is about profits and management has not choice but to maximize profits or shareholder value.

9. Companies are working communities based on people. The company needs high learning and innovation desparately. Yet the company is structured like a 19th century industrial company based on assets. The employee receives some of the assets in exchange for talents and contributions.

10. Putting profit before people did not work in the old economy nor in the new economy.

11. Historically, land ownership was the source of wealth accumulation and more land ownership meant more wealth. The rise of corporation require capital equity to expand and grow. Land was exchanged for equity to be invested in corporation. Capital equity markets grew as corporations grew and wealth was viewed as ownership in the company. When production exceeds demand, savings occurs. Savings were making their way back into production. Adding capital to production processes great increased output. Capital became the critical factor to production.

12. In 1999, banks,mutual funds, and pensions surpasses $10 trillion.

13. Monies held by savings and institutions was $16 trillion

14. Capital markets are a buyers market. Capital is no longer the scarce production factor.

15. Going up are capital poor but brain rich companies. Talent is scarce.

16. Managers need to make use of talent immediately and increase the learn capacity of the communities.

17. Learning will be key to competitive survival.
Posted:10/13/2012


Transonic Combustion put its new fuel-injection technology into this sports cars

Info: 1. Transonic Combustion has developed a system to improve the efficiency of gasoline engines.

2. A test vehicle achieved 64 miles per gallon in highway driving.

3. The key is heating and pressurizing gasoline before injecting it into the combustion chamber, says Mike Rocke. The gas in supercritical state allows for very fast and clean combustion.

4. “It is time for a renaissance for internal combustion engines.

5. Once the fuel is injected into the piston, the heat and pressure are enough to cause the fuel to combust without a spark

6. Reference Link
Posted:3/14/2010

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